Prostate cancer outcome and tissue levels of metal ions
Identifieur interne : 000012 ( Main/Exploration ); précédent : 000011; suivant : 000013Prostate cancer outcome and tissue levels of metal ions
Auteurs : Andrey G. Sarafanov ; Todor I. Todorov [États-Unis] ; José A. Centeno ; Virgilia Macias [États-Unis] ; Weihua Gao [États-Unis] ; Wei‐Min Liang [États-Unis] ; Craig Beam [États-Unis] ; Marion A. Gray [Australie] ; André A. Kajdacsy‐Balla [États-Unis]Source :
- The Prostate [ 0270-4137 ] ; 2011-08-01.
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Abstract
BACKGROUND: There are several studies examining prostate cancer and exposure to cadmium, iron, selenium, and zinc. Less data are available on the possible influence of these metal ions on prostate cancer outcome. This study measured levels of these ions in prostatectomy samples in order to examine possible associations between metal concentrations and disease outcome. METHODS: We obtained formalin fixed paraffin embedded tissue blocks of prostatectomy samples of 40 patients with PSA recurrence, matched 1:1 (for year of surgery, race, age, Gleason grading, and pathology TNM classification) with tissue blocks from 40 patients without recurrence (n = 80). Case–control pairs were compared for the levels of metals in areas adjacent to tumors. Inductively coupled plasma‐mass spectrometry (ICP‐MS) was used for quantification of Cd, Fe, Zn, and Se. RESULTS: Patients with biochemical (PSA) recurrence of disease had 12% lower median iron (95 µg/g vs. 111 µg/g; P = 0.04) and 21% lower zinc (279 µg/g vs. 346 µg/g; P = 0.04) concentrations in the normal‐appearing tissue immediately adjacent to cancer areas. Differences in cadmium (0.489 µg/g vs. 0.439 µg/g; 4% higher) and selenium (1.68 µg/g vs. 1.58 µg/g; 5% higher) levels were not statistically significant in recurrence cases, when compared to non‐recurrences (P = 0.40 and 0.21, respectively). CONCLUSIONS: There is an association between low zinc and low iron prostate tissue levels and biochemical recurrence in prostate cancer. Whether these novel findings are a cause or effect of more aggressive tumors, or whether low zinc and iron prostatic levels raise implications for therapy, remains to be investigated. Prostate 71:1231–1238, 2011. © 2011 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/pros.21339
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Gray</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Kajdacsy Alla, Andre A" sort="Kajdacsy Alla, Andre A" uniqKey="Kajdacsy Alla A" first="André A." last="Kajdacsy‐Balla">André A. 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Less data are available on the possible influence of these metal ions on prostate cancer outcome. This study measured levels of these ions in prostatectomy samples in order to examine possible associations between metal concentrations and disease outcome. METHODS: We obtained formalin fixed paraffin embedded tissue blocks of prostatectomy samples of 40 patients with PSA recurrence, matched 1:1 (for year of surgery, race, age, Gleason grading, and pathology TNM classification) with tissue blocks from 40 patients without recurrence (n = 80). Case–control pairs were compared for the levels of metals in areas adjacent to tumors. Inductively coupled plasma‐mass spectrometry (ICP‐MS) was used for quantification of Cd, Fe, Zn, and Se. RESULTS: Patients with biochemical (PSA) recurrence of disease had 12% lower median iron (95 µg/g vs. 111 µg/g; P = 0.04) and 21% lower zinc (279 µg/g vs. 346 µg/g; P = 0.04) concentrations in the normal‐appearing tissue immediately adjacent to cancer areas. Differences in cadmium (0.489 µg/g vs. 0.439 µg/g; 4% higher) and selenium (1.68 µg/g vs. 1.58 µg/g; 5% higher) levels were not statistically significant in recurrence cases, when compared to non‐recurrences (P = 0.40 and 0.21, respectively). CONCLUSIONS: There is an association between low zinc and low iron prostate tissue levels and biochemical recurrence in prostate cancer. Whether these novel findings are a cause or effect of more aggressive tumors, or whether low zinc and iron prostatic levels raise implications for therapy, remains to be investigated. Prostate 71:1231–1238, 2011. © 2011 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Colorado</li><li>Illinois</li></region></list><tree><noCountry><name sortKey="Centeno, Jose A" sort="Centeno, Jose A" uniqKey="Centeno J" first="José A." last="Centeno">José A. Centeno</name><name sortKey="Sarafanov, Andrey G" sort="Sarafanov, Andrey G" uniqKey="Sarafanov A" first="Andrey G." last="Sarafanov">Andrey G. Sarafanov</name></noCountry><country name="États-Unis"><region name="Colorado"><name sortKey="Todorov, Todor I" sort="Todorov, Todor I" uniqKey="Todorov T" first="Todor I." last="Todorov">Todor I. Todorov</name></region><name sortKey="Beam, Craig" sort="Beam, Craig" uniqKey="Beam C" first="Craig" last="Beam">Craig Beam</name><name sortKey="Gao, Weihua" sort="Gao, Weihua" uniqKey="Gao W" first="Weihua" last="Gao">Weihua Gao</name><name sortKey="Kajdacsy Alla, Andre A" sort="Kajdacsy Alla, Andre A" uniqKey="Kajdacsy Alla A" first="André A." last="Kajdacsy‐Balla">André A. Kajdacsy‐Balla</name><name sortKey="Liang, Wei In" sort="Liang, Wei In" uniqKey="Liang W" first="Wei‐Min" last="Liang">Wei‐Min Liang</name><name sortKey="Macias, Virgilia" sort="Macias, Virgilia" uniqKey="Macias V" first="Virgilia" last="Macias">Virgilia Macias</name></country><country name="Australie"><noRegion><name sortKey="Gray, Marion A" sort="Gray, Marion A" uniqKey="Gray M" first="Marion A." last="Gray">Marion A. Gray</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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